Serzone (nefazodone)

Serzone (nefazodone)

Serzone (nefazodone)

This drug is in one of the newer classes of selective serotonin reuptake inhibitors (SSRIs) that work on blocking the reabsorption of certain neurotransmitters. The brand version of the drug has been pulled from the US market as of 2004 due to liver toxicity, however generic formulations may still be available.

What is Serzone?



Serzone is generally used in the treatment of depression and is in a class of medications called antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. Like other antidepressants, it works by increasing serotonin levels in the brain and should not be taken with MAOIs. Serzone can increase the levels of other drugs in the body such as Halcion or Xanax.

Uses of Serzone

Serzone use has proven helpful for those suffering from PTSD and seems to have a lower incidence of sedation than Trazodone. Often, Serzone is used in drug rehab facilities for treatment of anxiety.

Side Effects of Serzone

  • Changes in sleep patterns
  • Panic attacks
  • Irritability
  • Anger
  • Rapid speech
  • Abdominal pain
  • Nausea
  • Yellow eyes
  • Dry mouth

More Severe Side Effects of Serzone

  • Blurred vision
  • Lightheadedness
  • Itchiness

In 2001, the FDA required a black box warning to be placed on packaging for Serzone, as there was evidence leading to increased risk of liver damage. The warning was updated in 2002.

There are a number of drugs such as Xanax, Ativan, Haldol, Dilantin and Tefretol that should not be taken in combination with Serzone as their combination can cause excessive sedation or increase toxicity in the liver.

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